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Adderall (mixed amphetamine salts) drives mitochondria into a damaging overdrive state by spiking dopamine and norepinephrine far beyond physiological capacity. It forces these neurotransmitters out of storage vesicles and reverses their transporters, flooding the synapse while blocking reuptake. Excess dopamine and norepinephrine sitting unshielded in the cytosol are rapidly metabolized by monoamine oxidase, producing hydrogen peroxide and reactive quinones that directly attack mitochondrial pr