eLife

Molidustat Targets a Synthetic Lethal Vulnerability in APC-Mutant Colorectal Cancer through GSTP1 and PHD2 Co-Inhibition

This important paper substantially advances our understanding of how Molidustat may work, beyond its canonical role, by identifying its therapeutic targets in cancer. This study presents a compelling ...

Marathon’s 'Escape will make me God' isn’t a metaphor — it’s a legit threat

In just a few short months, Marathon has minted a highly quotable line: “Escape will make me God.” It’s also, according to ...
eLife

Serotonergic modulation of motor subspace dynamics drives a sleep-independent quiescent state

The dorsal raphe nucleus (DRN) serotonergic (5-HT) system has been implicated in regulating sleep and motor control; however, its specific role remains controversial. In this study, we found that ...

In 'Margo's Got Money Troubles,' they're a dysfunctional, ferociously loving family

The Apple TV series, created by David E. Kelley and based on Rufi Thorpe's 2024 novel, stars Michelle Pfeiffer, Elle Fanning ...