How a tiny circle of repeat offenders poisoned 100s of gold-standard medical trials for over a decade

Randomized Controlled Trials (RCTs) are the gold standard of medical research as random assignment approach helps eliminate ...
Fierce Biotech

Small pools, big ideas: How the rare disease community is reimagining clinical trials

The traditional gold standard of clinical trials with a randomized, placebo-controlled design involving hundreds of patients ...
The New England Journal of Medicine

Ivermectin to Control Malaria — A Cluster-Randomized Trial

Malaria control and elimination is threatened by the spread of insecticide resistance and behavioral adaptation of vectors. Whether mass administration of ivermectin, a broad-spectrum antiparasitic ...
Tobacco Control

Effectiveness of a school-based health education intervention on tobacco use intention among adolescents: a cluster-randomised controlled trial

Background Adolescence is a critical period for tobacco initiation, and intention to use tobacco strongly predicts uptake. In ...
ascopubs.org

Efficacy and safety of trastuzumab deruxtecan for metastatic HER2+ and HER2-low breast cancer: A systematic review and meta-analysis of randomised controlled trials.

A randomized, double-blind, three-arm, parallel group, phase 1 study to assess the pharmacokinetics, safety, and tolerability of PERT-IJS following a single dose of 420 mg intravenous infusion ...
BMJ

Efficacy of cognitive functional therapy for pain intensity and disability in patients with non-specific chronic low back pain: a randomised sham-controlled trial

2 Postgraduate Program in Rehabilitation Sciences, Augusto Motta University Centre - UNISUAM, Rio de Janeiro, Brazil Objective This study investigated the efficacy of cognitive functional therapy (CFT ...