A role for the enzymes adenosine deaminase (adenosine aminohydrolase, EC 3.5.4.4) and purine-nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) in the ...

In recent years, the number of targeted cancer drugs has continued to rise. However, conventional chemotherapeutic agents still play an important role in cancer treatment. These include platinum-based ...

In recent years, the number of targeted cancer drugs has continued to rise. However, conventional chemotherapeutic agents still play an important role in cancer treatment. These include platinum-based ...

A compound that inhibits the growth of BCL-2–dependent tumours has been re-engineered to prevent the concurrent inhibition of the BCL-X L protein that protects platelets, report Andrew Souers and ...

Comparison of DNA hypomethylating agents and low dose cytarabine in elderly acute myeloid leukemia patients: A meta-analysis. This is an ASCO Meeting Abstract from the 2015 ASCO Annual Meeting I. This ...

One of the puzzles of Parkinson pathology is why death comes to only a subpopulation of neurons in the midbrain. The dopaminergic neurons in the substantia nigra (SN) and their projections are lost, ...

ANTIMICROBIAL agents encompass both synthetic compounds and natural products or antibiotics. The vast majority of antimicrobial drugs synthesized or isolated do not possess the requisite selectivity ...

MIAMI--(BUSINESS WIRE)--A major scientific breakthrough in the development of novel cancer therapeutics targeting the Notch pathway has been published online ahead of print in the journal Cancer ...

Lanthanides are a series of critical elements widely used in multiple industries, such as optoelectronics and healthcare. Although initially considered to be of low toxicity, concerns have emerged ...

Researchers recently demonstrated that platinum nanoparticles can be used to kill liver cancer cells with greater selectivity than existing cancer drugs. In recent years, the number of targeted cancer ...