Chronic kidney disease (CKD) is a progressive condition that begins with tissue damage and gradually leads to loss of kidney function. The condition, which affects about 10% of the global population, ...

Using human-induced pluripotent stem cell-derived kidney organoids, researchers from Science Tokyo uncovered how abnormal Hippo signaling drives fibrosis in nephronophthisis, a genetic kidney disorder ...

Researchers developed tubuloids from adult kidney cells. When exposed to cisplatin, the model replicated key steps in the chronic kidney disease progression, including DNA damage, cellular senescence, ...