Protein folding raises some of biology's greatest theoretical challenges. It also lies at the root of many diseases. For example, the fundamental question of whether a protein's final tertiary ...

Repeat proteins, defined by sequential arrays of short structural motifs, offer an intriguing departure from the folding behaviour of conventional globular proteins. Their modular architecture enables ...

Researchers have developed a method to evaluate the folding stability of a million proteins simultaneously. DNA libraries were used to generate protein -- DNA complexes that were treated with enzymes ...

Protein molecules require a defined shape in order to function. When they are created, their building blocks are therefore linked together in a very specific way. Researchers are now taking a closer ...

When a protein folds, its string of amino acids wiggles and jiggles through countless conformations before it forms a fully folded, functional protein. This rapid and complex process is hard to ...

Just as a misshapen key can't open a lock, the proteins in our cells need to have the correct 3D shape to function properly. And defects in a protein's structure can cause diseases. Proteins are ...

Most of the activities that go on inside cells—the activities that keep us living, breathing, thinking animals—are handled by proteins. They allow cells to communicate with each other, run a cell’s ...

Artificial intelligence (AI) is reshaping the scientific landscape, offering fantastic solutions to some of the most pressing global challenges. From combating climate change to transforming ...

"The protein must backtrack in the folding process to correct the mistake, which takes time and is energetically expensive. The demonstration of this mechanism helps expand our understanding of how ...

WEST LAFAYETTE, Ind. — The shared culprit in a slew of diseases — cancers, neurodegenerative diseases, diabetes — is molecules our cells have made incorrectly. Think of them as proteins gone wrong.

At the recent ELRIG Drug Discovery conference, Technology Networks<i/> spoke with Dr. Kundan Sharma to learn more about how cell-free expression platforms are transforming membrane protein research.