Systemic sclerosis causes the skin to tighten and harden resulting in a potentially fatal autoimmune condition that is associated with lung fibrosis and kidney disease. University of Michigan Health ...

The intestinal epithelium undergoes rapid renewal every 3–5 days, a process driven by intestinal stem cells (ISCs) located at ...

Within the family of cell membrane lipids known as phosphoinositides and the kinase enzymes that regulate them, phosphoinositide 3-kinases (PI3Ks) have been cast in a starring role as scientists study ...

A recent article posted to the bioRxiv* preprint server illustrated that the activation of the Hippo signaling pathway upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection aids ...

The same genes could hold the key to regenerating cells in the ear and eye, according to a new mouse study. Researchers focused on a group of interacting genes called the Hippo pathway, which serve as ...

Two seemingly disparate signaling pathways -- one that controls organ size in fruit flies and another important for the growth of embryos -- interact in embryonic mouse hearts to restrict cell ...

Schwannomas are the most common nerve sheath tumor. They can occur in anyone but are also linked to a hereditary condition known as Neurofibromatosis Type II (NF2). With an urgent need for new ...